Genetic polymorphisms of NFκB1-94ins/delATTG and NFκBIA-881A/G genes in Egyptian patients with colorectal cancer
| 作者： | Mohamed Ragab Youssef, Zeinab Ibraheim Attia, Rizk Ahmed El-Baz, Sameh Roshdy, Ahmad Settin |
| 作者单位： |
1Tanta University 2Mansoura University |
| 刊名： | Familial Cancer, 2017, Vol.16 (4), pp.517-524 |
| 来源数据库： | Springer Nature Journal |
| DOI： | 10.1007/s10689-017-9992-y |
| 关键词： | NFκB1-94ins/delATTG; NFκBIA-881A/G; Colorectal cancer; Egypt; |
| 英文摘要： | To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the same locality. For all participants, genetic polymorphisms of NFκB1-94ins/delATTG (rs28362491) and NFκBIA-881A/G (rs3138053) were detected by using restriction fragment length polymorphism polymerase chain reaction (RFLP–PCR). CRC patients showed a significantly higher frequency of the NFκB1-94ins/ins genotype than controls (30 vs. 4.7%) that was significant in the recessive (OR 17.69, 95% CI 5.41–57.82, p < 0.0001) and codominant models (OR 18.28, 95% CI 4.87–68.6, p < 0.0001). The NFκB1-94ins allele frequency was... |
| 原始语种摘要： | To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the same locality. For all participants, genetic polymorphisms of NFκB1-94ins/delATTG (rs28362491) and NFκBIA-881A/G (rs3138053) were detected by using restriction fragment length polymorphism polymerase chain reaction (RFLP–PCR). CRC patients showed a significantly higher frequency of the NFκB1-94ins/ins genotype than controls (30 vs. 4.7%) that was significant in the recessive (OR 17.69, 95% CI 5.41–57.82, p < 0.0001) and codominant models (OR 18.28, 95% CI 4.87–68.6, p < 0.0001). The NFκB1-94ins allele frequency was... |
