Genetic polymorphisms of NFκB1-94ins/delATTG and NFκBIA-881A/G genes in Egyptian patients with colorectal cancer
作者: Mohamed Ragab YoussefZeinab Ibraheim AttiaRizk Ahmed El-BazSameh RoshdyAhmad Settin
作者单位: 1Tanta University
2Mansoura University
刊名: Familial Cancer, 2017, Vol.16 (4), pp.517-524
来源数据库: Springer Journal
DOI: 10.1007/s10689-017-9992-y
关键词: NFκB1-94ins/delATTGNFκBIA-881A/GColorectal cancerEgypt
英文摘要: To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the same locality. For all participants, genetic polymorphisms of NFκB1-94ins/delATTG (rs28362491) and NFκBIA-881A/G (rs3138053) were detected by using restriction fragment length polymorphism polymerase chain reaction (RFLP–PCR). CRC patients showed a significantly higher frequency of the NFκB1-94ins/ins genotype than controls (30 vs. 4.7%) that was significant in the recessive (OR 17.69, 95% CI 5.41–57.82, p < 0.0001) and codominant models (OR 18.28, 95% CI 4.87–68.6, p < 0.0001). The NFκB1-94ins allele frequency was...
原始语种摘要: To assess the association of genetic polymorphisms of NFκB1 and NFκBIA genes with the susceptibility to colorectal cancer (CRC). Subjects included 100 Egyptian patients with CRC (60 males and 40 females) in addition to 85 healthy controls (47 males and 38 females) from the same locality. For all participants, genetic polymorphisms of NFκB1-94ins/delATTG (rs28362491) and NFκBIA-881A/G (rs3138053) were detected by using restriction fragment length polymorphism polymerase chain reaction (RFLP–PCR). CRC patients showed a significantly higher frequency of the NFκB1-94ins/ins genotype than controls (30 vs. 4.7%) that was significant in the recessive (OR 17.69, 95% CI 5.41–57.82, p < 0.0001) and codominant models (OR 18.28, 95% CI 4.87–68.6, p < 0.0001). The NFκB1-94ins allele frequency was...
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影响因子:1.935 (2012)

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关键词翻译
关键词翻译
  • BIA Bahrain International Airport
  • Egyptian 埃及的
  • genetic 遗传的
  • colorectal 结肠直肠的
  • controls 控制机构
  • increased 增加
  • higher 
  • locality 产地
  • cancer 癌症
  • polymorphism 多晶形