Formation and repair of DNA-protein crosslink damage
作者: Naeh L. Klages-MundtLei Li
作者单位: 1The University of Texas MD Anderson Cancer Center
2The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences
刊名: Science China Life Sciences, 2017, Vol.60 (10), pp.1065-1076
来源数据库: Springer Journal
DOI: 10.1007/s11427-017-9183-4
关键词: DNA-protein crosslinksNucleotide excision repairSPRTNFanconi anemia
英文摘要: DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a DNA strand—are one of the most deleterious and understudied forms of DNA damage, posing as steric blockades to transcription and replication. If not properly repaired, these lesions can lead to mutations, genomic instability, and cell death. DPCs can be induced endogenously or through environmental carcinogens and chemotherapeutic agents. Endogenously, DPCs are commonly derived through reactions with aldehydes, as well as through trapping of various enzymatic intermediates onto the DNA. Proteolytic cleavage of the protein moiety of a DPC is a general strategy for removing the lesion. This can be accomplished...
原始语种摘要: DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a DNA strand—are one of the most deleterious and understudied forms of DNA damage, posing as steric blockades to transcription and replication. If not properly repaired, these lesions can lead to mutations, genomic instability, and cell death. DPCs can be induced endogenously or through environmental carcinogens and chemotherapeutic agents. Endogenously, DPCs are commonly derived through reactions with aldehydes, as well as through trapping of various enzymatic intermediates onto the DNA. Proteolytic cleavage of the protein moiety of a DPC is a general strategy for removing the lesion. This can be accomplished...
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影响因子:2.024 (2011)

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关键词翻译
关键词翻译
  • protein 蛋白质
  • DNA Deoxyribonucleic Acid
  • repair 修理
  • homologous 同结构型的
  • excision 切除
  • genomic 染色体组的
  • likely 大概
  • DPC Data Processing Center
  • anemia 贫血
  • strand 海滨