High-risk individuals’ perceptions of reproductive genetic testing for CDH1 mutations
作者: Nina HallowellShirlene BadgerSue RichardsonCarlos CaldasRichard H. HardwickRebecca C. FitzgeraldJulia Lawton
作者单位: 1University of Oxford
2University of Cambridge
3Cambridge University Hospitals Trust, Addenbrookes Hospital
4University of Edinburgh
刊名: Familial Cancer, 2017, Vol.16 (4), pp.531-535
来源数据库: Springer Journal
DOI: 10.1007/s10689-017-9976-y
关键词: Hereditary diffuse gastric cancer (HDGC)E-Cadherin ( CDH1 )Reproductive genetic testingPreimplantation genetic diagnosis (PGD)Prenatal diagnosis (PND)Hereditary cancer
英文摘要: Reproductive genetic testing- PreNatal Diagnosis (PND) and Preimplantation Genetic Diagnosis (PGD)—for CDH1 mutations associated with Hereditary Diffuse Gastric Cancer (HDGC)is available in the UK. This qualitative interview study examined high-risk individuals’ (n = 35) views of CDH1 reproductive genetic testing. Interviewees generally regarded reproductive genetic testing as an acceptable form of HDGC risk management. However, some were concerned that their genetic risks required them to plan reproduction and anticipated difficulties communicating this to reproductive partners. Individuals had a preference for PGD over PND because it avoided the need for a termination of pregnancy. However, those who had not yet had children expressed concerns about having to undergo IVF procedures and...
原始语种摘要: Reproductive genetic testing- PreNatal Diagnosis (PND) and Preimplantation Genetic Diagnosis (PGD)—for CDH1 mutations associated with Hereditary Diffuse Gastric Cancer (HDGC)is available in the UK. This qualitative interview study examined high-risk individuals’ (n = 35) views of CDH1 reproductive genetic testing. Interviewees generally regarded reproductive genetic testing as an acceptable form of HDGC risk management. However, some were concerned that their genetic risks required them to plan reproduction and anticipated difficulties communicating this to reproductive partners. Individuals had a preference for PGD over PND because it avoided the need for a termination of pregnancy. However, those who had not yet had children expressed concerns about having to undergo IVF procedures and...
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影响因子:1.935 (2012)

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关键词翻译
关键词翻译
  • genetic 遗传的
  • reproductive 再生产的
  • testing 测试
  • available 可供应的
  • termination 终止
  • required 必需
  • anticipated 预先
  • expressed 榨出的
  • acceptable 可接受的
  • about 大约