An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo
作者: Andreas KuehneJanosch HildebrandJoern SoehleHorst WenckLara TerstegenStefan GallinatAnja KnottMarc WinnefeldNicola Zamboni
作者单位: 1ETH Zurich
2Life Science Zurich Graduate School
3Coburg University of Applied Sciences and Arts
4Skin Research Center
刊名: BMC Genomics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12864-017-3547-3
关键词: SkinAgingMetabolismMetabolomicsTranscriptomicsSystems biology
英文摘要: Aging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier function. Besides known age-related alterations like DNA-methylation changes, metabolic adaptations have been recently linked to impaired skin function in elder humans. Understanding of these metabolic adaptations in aged skin is of special interest to devise topical treatments that potentially reverse or alleviate age-dependent skin deterioration and the occurrence of skin disorders.
原始语种摘要: Aging human skin undergoes significant morphological and functional changes such as wrinkle formation, reduced wound healing capacity, and altered epidermal barrier function. Besides known age-related alterations like DNA-methylation changes, metabolic adaptations have been recently linked to impaired skin function in elder humans. Understanding of these metabolic adaptations in aged skin is of special interest to devise topical treatments that potentially reverse or alleviate age-dependent skin deterioration and the occurrence of skin disorders.
全文获取路径: Springer  (合作)
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影响因子:4.397 (2012)

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关键词翻译
关键词翻译
  • barrier 堡坝
  • function 函数
  • recently 近来
  • special 特别的
  • metabolic 新陈代谢的
  • integrative 综合
  • identify 视为同一
  • potentially 可能地
  • occurrence 事件
  • devise 设计