Light/dark phase-dependent spontaneous activity is maintained in dopamine-deficient mice
作者: Masayo FujitaYoko HaginoTaishi TakedaShinya KasaiMiho TanakaYukio TakamatsuKazuto KobayashiKazutaka Ikeda
作者单位: 1Tokyo Metropolitan Institute of Medical Science
2Fukushima Medical University
刊名: Molecular Brain, 2017, Vol.10 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13041-017-0329-4
关键词: DopamineDopamine-deficient miceLight/dark phaseSpontaneous activity
英文摘要: Dopamine is important for motor control and involved in the regulation of circadian rhythm. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxyphenylalanine (L-DOPA) when dopamine was almost completely depleted. DD mice did not initially exhibit hyperactivity in their home cages, but the animals exhibited hyperactivity several hours after the last L-DOPA injection. The regulation of motor activity in a novel environment and in home cages may be different. A previous study reported that DD mice became active again approximately 24 h after the last L-DOPA injection. One speculation was that light/dark phase-dependent spontaneous activity might be maintained despite dopamine deficiency. The present...
原始语种摘要: Dopamine is important for motor control and involved in the regulation of circadian rhythm. We previously found that dopamine-deficient (DD) mice became hyperactive in a novel environment 72 h after the last injection of L-3,4-dihydroxyphenylalanine (L-DOPA) when dopamine was almost completely depleted. DD mice did not initially exhibit hyperactivity in their home cages, but the animals exhibited hyperactivity several hours after the last L-DOPA injection. The regulation of motor activity in a novel environment and in home cages may be different. A previous study reported that DD mice became active again approximately 24 h after the last L-DOPA injection. One speculation was that light/dark phase-dependent spontaneous activity might be maintained despite dopamine deficiency. The present...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:4.202 (2012)

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关键词翻译
关键词翻译
  • dopamine 多巴胺
  • maintained 保持着的
  • activity 活度
  • spontaneous 自发的
  • injection 贯入
  • hyperactive 极度活跃的
  • phase 相位
  • locomotor 运动器
  • suppressed 被抑制的
  • completely 完全