Demethylation of methionine and keratin damage in human hair
作者: Kamila BorowczykJoanna SuliburskaHieronim Jakubowski
作者单位: 1Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, International Center for Public Health
2Department of Environmental Chemistry, University of Łódź
3Department of Human Nutrition and Hygiene, Poznań University of Life Sciences
4Department of Biochemistry and Biotechnology, Poznań University of Life Sciences
刊名: Amino Acids, 2018, Vol.50 (5), pp.537-546
来源数据库: Springer Journal
DOI: 10.1007/s00726-018-2545-3
关键词: Hair keratin damageHomocysteineMethionine demethylationCopperIron
英文摘要: Abstract(#br)Growing human head hair contains a history of keratin and provides a unique model for studies of protein damage. Here, we examined mechanism of homocysteine (Hcy) accumulation and keratin damage in human hair. We found that the content of Hcy-keratin increased along the hair fiber, with levels 5–10-fold higher levels in older sections at the hair’s tip than in younger sections at hair’s base. The accumulation of Hcy led to a complete loss of keratin solubility in sodium dodecyl sulfate. The increase in Hcy-keratin was accompanied by a decrease in methionine-keratin. Levels of Hcy-keratin were correlated with hair copper and iron in older hair. These relationships were recapitulated in model experiments in vitro, in which Hcy generation from Met exhibited a similar dependence...
全文获取路径: Springer  (合作)
影响因子:3.914 (2012)