Synthesis of Conjugates of Lupane-Type Pentacyclic Triterpenoids with 2-Aminoethane- and N -Methyl-2-Aminoethanesulfonic Acids. Assessment of in vitro Toxicity
作者: N. G. KomissarovaS. N. DubovitskiiO. V. ShitikovaE. M. VyrypaevL. V. SpirikhinE. M. EropkinaT. G. LobovaM. Yu. EropkinM. S. Yunusov
作者单位: 1Russian Academy of Sciences
2Ministry of Health of the Russian Federation
刊名: Chemistry of Natural Compounds, 2017, Vol.53 (5), pp.907-914
来源数据库: Springer Nature Journal
DOI: 10.1007/s10600-017-2153-6
关键词: BetulinBetulinic acidBetulonic acid2-aminoethanesulfonic acidN -methyl-2-aminoethanesulfonic acidToxicity in vitro
原始语种摘要: Conjugates of betulin and betulinic and betulonic acids with 2-aminoethane- and N-methyl-2-aminoethanesulfonic acids were synthesized for the first time and were interesting as potential biologically active compounds. Experiments in vitro in MDCK cell culture using the MTT assay found that betulin and betulinic-acid derivatives with aminoethanesulfonic acid bound to triterpene C-3 or C-28 through an ester linker were less toxic than the native compounds.
全文获取路径: Springer Nature  (合作)
影响因子:0.599 (2012)

  • betulin 桦木脑
  • triterpene 三萜烯
  • ester 
  • potential 
  • methyl 甲基
  • aminoethane 乙胺
  • vitro 体外
  • linker 链接编辑程序
  • bound 
  • through 经过