Fibrin-specific and effective clot lysis requires both plasminogen activators and for them to be in a sequential rather than simultaneous combination
作者: R. PannellS. LiV. Gurewich
作者单位: 1Harvard Medical School
刊名: Journal of Thrombosis and Thrombolysis, 2017, Vol.44 (2), pp.210-215
来源数据库: Springer Nature Journal
DOI: 10.1007/s11239-017-1514-0
关键词: FibrinolysisTPAProuPASynergySequential lysis
原始语种摘要: Thrombolysis with tissue plasminogen activator (tPA) has been a disappointment and has now been replaced by an endovascular procedure whenever possible. Nevertheless, thrombolysis remains the only means by which circulation in a thrombosed artery can be restored rapidly. In contrast to tPA monotherapy, endogenous fibrinolysis uses both tPA and urokinase plasminogen activator (uPA), whose native form is a proenzyme, prouPA. This combination is remarkably effective as evidenced by the fibrin degradation product, d -dimer, which is invariably present in plasma. The two activators have complementary mechanisms of plasminogen activation and are synergistic in combination. Since tPA initiates fibrinolysis when released from the vessel wall and prouPA is in the blood, they induce fibrinolysis...
全文获取路径: Springer Nature  (合作)
影响因子:1.985 (2012)

  • plasminogen 胞浆素原
  • fibrinolysis 纤维素分解
  • effective 有效的
  • sequential 连续的
  • simultaneous 同时的
  • combination 聚形
  • thrombosed 形成血栓的
  • specific 
  • activator 活化剂
  • endovascular 血管内的