DIGNiFI: Discovering causative genes for orphan diseases using protein-protein interaction networks
作者: Xiaoxia LiuZhihao YangHongfei LinMichael SimmonsZhiyong Lu
作者单位: 1Dalian University of Technology
2National Institutes of Health
刊名: BMC Systems Biology, 2017, Vol.11 (3)
来源数据库: Springer Journal
DOI: 10.1186/s12918-017-0402-8
关键词: Orphan diseaseGenetic diseaseProtein-protein interaction networksEye disease
英文摘要: An orphan disease is any disease that affects a small percentage of the population. Orphan diseases are a great burden to patients and society, and most of them are genetic in origin. Unfortunately, our current understanding of the genes responsible for inherited orphan diseases is still quite limited. Developing effective computational algorithms to discover disease-causing genes would help unveil disease mechanisms and may enable better diagnosis and treatment.
原始语种摘要: An orphan disease is any disease that affects a small percentage of the population. Orphan diseases are a great burden to patients and society, and most of them are genetic in origin. Unfortunately, our current understanding of the genes responsible for inherited orphan diseases is still quite limited. Developing effective computational algorithms to discover disease-causing genes would help unveil disease mechanisms and may enable better diagnosis and treatment.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.982 (2012)

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关键词翻译
关键词翻译
  • orphan 孤行
  • protein 蛋白质
  • interaction 相互酌
  • causative 表示原因的
  • understanding 理解
  • genetic 遗传的
  • computational 计算的
  • unveil 拉开...的帷幕
  • percentage 百分数
  • responsible 负责的