1,6- O , O -Diacetylbritannilactone Inhibits Eotaxin-1 and ALOX15 Expression Through Inactivation of STAT6 in A549 Cells
作者: Xi ChenNing JiNan QinSheng-an TangRan WangYuling QiuHongquan DuanDexin KongMeihua Jin
作者单位: 1Tianjin Medical University
2Tianjin Eye Hospital
刊名: Inflammation, 2017, Vol.40 (6), pp.1967-1974
来源数据库: Springer Journal
DOI: 10.1007/s10753-017-0637-y
关键词: 16- OO -diacetylbritannilactoneEotaxin-1ALOX-15STAT6JAK3
英文摘要: 1,6- O , O -Diacetylbritannilactone (OODBL), a plant sesquiterpene lactone, was previously reported to show multiple pharmacological effects such as anti-cancer and anti-inflammatory activities. In this study, we investigated the anti-inflammatory effect of OODBL on interleukin (IL)-4-induced signal transducer and activator of transcription 6 (STAT6) signaling pathway in human lung A549 cells. We found that OODBL dramatically inhibited IL-4-induced messenger RNA (mRNA) expression of eotaxin-1 and arachidonate 15-lipoxygenase-1 (ALOX15) in a dose-dependent manner. To clarify the action mechanism of OODBL, we examined the effect of OODBL on activation of STAT6. OODBL decreased both STAT6 phosphorylation and reporter gene activity. Furthermore, OODBL suppressed phosphorylation of Janus...
原始语种摘要: 1,6- O , O -Diacetylbritannilactone (OODBL), a plant sesquiterpene lactone, was previously reported to show multiple pharmacological effects such as anti-cancer and anti-inflammatory activities. In this study, we investigated the anti-inflammatory effect of OODBL on interleukin (IL)-4-induced signal transducer and activator of transcription 6 (STAT6) signaling pathway in human lung A549 cells. We found that OODBL dramatically inhibited IL-4-induced messenger RNA (mRNA) expression of eotaxin-1 and arachidonate 15-lipoxygenase-1 (ALOX15) in a dose-dependent manner. To clarify the action mechanism of OODBL, we examined the effect of OODBL on activation of STAT6. OODBL decreased both STAT6 phosphorylation and reporter gene activity. Furthermore, OODBL suppressed phosphorylation of Janus...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.457 (2012)

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关键词翻译
关键词翻译
  • STAT 静止的
  • inflammatory 激怒的
  • allergic 变应性的
  • airway 航路
  • interleukin 白细胞间介素
  • induced 感应的
  • activator 活化剂
  • dramatically 戏剧性地
  • sesquiterpene 倍半萜烯
  • transcription 地名转写