Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus
作者: Muthu Sendhil KumaranAnuradha BishnoiNiharika SrivastavaSindhuja TekumallaKeshavamurthy VinayAlka BhatiaDavinder Parsad
作者单位: 1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research
2Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research
刊名: Archives of Dermatological Research, 2019, Vol.311 (7), pp.519-527
来源数据库: Springer Journal
DOI: 10.1007/s00403-019-01926-9
关键词: Lichen planusLichen planus pigmentosusInterleukins 1722 and 23Interferon gamma
英文摘要: Abstract(#br)Recent studies have noticed significant role of interleukin (IL)-17, 22, 23, Foxp3, interferon-gamma (IFN-γ) and Wnt5a in oral and cutaneous lichen planus (LP). This study was undertaken to assess whether similar expression exists in lichen planus pigmentosus (LPP). We recruited 30 patients of treatment-naïve ‘LPP’ (in absence of cutaneous/mucosal LP elsewhere, group 1), 10 patients having active treatment-naïve cutaneous ‘LP’ (group 2), 10 patients having ‘post-LP’ hyperpigmentation (in absence of active LP and off treatment for at least past 3 months, group 3), and 10 controls. Quantitative real-time polymerase chain reaction (qRT-PCR, peripheral blood mononuclear cells [PBMCs] and skin) and immunohistochemistry (IHC, skin) was performed. mRNA expression ( in PBMCs ) of...
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影响因子:2.708 (2012)

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