IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells
作者: Yu XiaPeng-Cheng CaiFan YuLiang XiongXin-Liang HeShan-Shan RaoFeng ChenXiang-Ping YangWan-Li MaHong Ye
作者单位: 1Huazhong University of Science and Technology
2Nanjing Medical University
3Key Laboratory of Pulmonary Diseases, Ministry of Health of China
刊名: Respiratory Research, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12931-017-0657-z
关键词: IL-4Bronchial epithelial cellsLipid raftsIntracellular Ca2 +MUC5ACAsthma
英文摘要: Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors NF-κB. The intracellular Ca2+ ([Ca2+]i) signal is required for activation of NF-κB. The transient receptor potential canonical 1 (TRPC1) channel has been shown to contribute for agonist-stimulated Ca2+ influx in some types of cells. However, the relationships among IL-4, TRPC1 and mucus overproduction in bronchial epithelial cells (BECs) in asthma are poorly understood.
原始语种摘要: Mucus overproduction is an important feature of asthma. Interleukin (IL)-4 is required for allergen-induced airway inflammation and mucus production. MUC5AC gene expression is regulated by transcript factors NF-κB. The intracellular Ca2+ ([Ca2+]i) signal is required for activation of NF-κB. The transient receptor potential canonical 1 (TRPC1) channel has been shown to contribute for agonist-stimulated Ca2+ influx in some types of cells. However, the relationships among IL-4, TRPC1 and mucus overproduction in bronchial epithelial cells (BECs) in asthma are poorly understood.
全文获取路径: Springer  (合作)
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影响因子:3.642 (2012)

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关键词翻译
关键词翻译
  • bronchial 支气管的
  • epithelial 上皮的
  • cells 麻风细胞
  • induced 感应的
  • asthma 哮喘
  • mucus 粘液
  • allergen 变应原
  • overproduction 过度生产
  • airway 航路
  • inflammation 炎症