Influence of short-term L-arginine supplementation on carbohydrate balance in rats with ischemia-reperfusion syndrome
作者: Hanna KraussPaweł BogdańskiPrzemysław SosnowskiJoanna SuliburskaAnna JabłeckaRafał JastakMaciej SassekPaweł MaćkowiakArtur CieślewiczDanuta Pupek-Musialik
作者单位: 1Department of Physiology,Poznan University of Medical Sciences,Święcickiego 6,Poznań,Poland
2Department of Internal Medicine, Metabolic Disorders and Hypertension,Poznan University of Medical Sciences,Szamarzewskiego 84,Poznań,Poland
3Department of Hygiene and Human Nutrition,Poznan University of Life Sciences,Wojska Polskiego 31,Poznań,Poland
4Department of Clinical Pharmacology,Poznan University of Medical Sciences,Dtuga 1/2,Poznań,Poland
5Department of Physiology and Biochemistry, Faculty of Animal Breeding and Biology,Poznan University of Life Sciences,Wotyhska 35,Poznań,Poland
刊名: Pharmacological Reports, 2012, Vol.64 (3), pp.635-642
来源数据库: Springer Nature Journal
DOI: 10.1016/S1734-1140(12)70859-9
关键词: L-arginineIschemiaInsulinGlucose
英文摘要: Abstract(#br)Background(#br)There are studies showing stimulative effect of arginine on insulin secretion. This mechanism is not fully explained. The effects of the impact of arginine on carbohydrate balance under the conditions of ischemia and reperfusion remain to be determined. The aim of this study is the evaluation of the influence of short-term L-arginine supplementation on the concentration of glucose and insulin in blood and insulin binding in rat skeletal muscle under the conditions of ischemia and reperfusion. Methods(#br)The study was conducted on male Wistar rats with average body mass 250 ± 30 g. Animals were divided into four groups: Group I - control, Group II - placebo, Group III - L-arginine 500 mg/kg/24 h for 5 days, Group IV - L-arginine and L-NAME (75 μmol/rat/24 h)...
全文获取路径: Springer Nature  (合作)
影响因子:1.965 (2012)