Novel hemostatic agents based on gelatin-microbial transglutaminase mix
作者: Fang LvXiaonan CongWenshu TangYiming HanYu TangYongrui LiuLiqiang SuMingyao LiuMingfei JinZhengfang Yi
作者单位: 1East China Normal University
刊名: Science China Life Sciences, 2017, Vol.60 (4), pp.397-403
来源数据库: Springer Journal
DOI: 10.1007/s11427-015-9019-x
关键词: Microbial transglutaminaseGelatinCrosslinkingBiomimetic hemostatic
英文摘要: Hemostasis is a major challenge in surgical procedures and traumas. Conventional hemostatic methods have limited efficacy and may cause additional tissue damage. In this study, we designed a novel hemostatic agent based on the in situ gel formation of gelatin cross-linked by a novel microbial transglutaminase (mTGase), in which the amino acid sequences differed from commercial mTGases. The new hemostatic agent showed the same biochemical crosslinking chemistry as the final stages of the blood coagulation cascade while using gelatin as a “structural” protein (rather than fibrin) and a calcium-independent mTGase as the crosslinking catalyst (rather than factor XIIIa). In rat liver hemostasis models, the hemostatic agent not only showed a similar hemostatic effect as that of...
原始语种摘要: Hemostasis is a major challenge in surgical procedures and traumas. Conventional hemostatic methods have limited efficacy and may cause additional tissue damage. In this study, we designed a novel hemostatic agent based on the in situ gel formation of gelatin cross-linked by a novel microbial transglutaminase (mTGase), in which the amino acid sequences differed from commercial mTGases. The new hemostatic agent showed the same biochemical crosslinking chemistry as the final stages of the blood coagulation cascade while using gelatin as a “structural” protein (rather than fibrin) and a calcium-independent mTGase as the crosslinking catalyst (rather than factor XIIIa). In rat liver hemostasis models, the hemostatic agent not only showed a similar hemostatic effect as that of...
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:2.024 (2011)

×
关键词翻译
关键词翻译
  • 弹性 
  • 因子 小瀑布
  • hemostatic 止血药
  • gelatin 
  • crosslinking 交联
  • hemostasis 止血
  • rather 宁愿
  • liver 
  • elasticity 
  • novel 长篇小说
  • cascade 小瀑布
  • agent 小瀑布