Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy
作者: Li LiPing TangShun LiXiang QinHong YangChunhui WuYiyao Liu
作者单位: 1University of Electronic Science and Technology of China
2Sichuan University
刊名: Medical Oncology, 2017, Vol.34 (10)
来源数据库: Springer Nature Journal
DOI: 10.1007/s12032-017-1039-6
关键词: Notch signaling pathwayCancerMetastasisMiRNATreatment strategy
原始语种摘要: Notch signaling pathway is evolutionarily conserved in mammals, which plays an important role in cell development and differentiation. In recent years, increasing evidence has shown that aberrant activation of Notch is associated with tumor process. Aberrant activation of Notch signaling pathway has been found in many different solid tumors can induce cell proliferation, metastasis and epithelial-mesenchymal transition. Notch receptor and its ligand are both single transmembrane protein, and Notch is activated when it binds to the Notch ligand of neighbor cells. The signal transduction of Notch signaling pathway is only between cells that are in contact with each other, which is independent of second messengers. Thus, Notch needs to cross talk with other signaling pathways, including...
全文获取路径: Springer Nature  (合作)
影响因子:2.147 (2012)

  • pathway 轨道
  • signaling 发信号
  • metastasis 同质蜕变
  • regulatory 控制的
  • transmembrane 横跨膜的
  • cancer 癌症
  • mesenchymal 间叶细胞的
  • receptor 接受体
  • target 目标
  • activation 活化