microRNA and thyroid hormone signaling in cardiac and skeletal muscle
作者: Duo ZhangYan LiShengnan LiuYu-cheng WangFeifan GuoQiwei ZhaiJingjing JiangHao Ying
作者单位: 1University of Chinese Academy of Sciences
2Shanghai Xuhui Central Hospital
3Fudan University
4Ministry of Health
5Institute for Nutritional Sciences
刊名: Cell & Bioscience, 2017, Vol.7 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13578-017-0141-y
关键词: Thyroid hormoneMiRNAHeartSkeletal muscle
英文摘要: Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant progress in our understanding of the molecular mechanisms that underlie TH action, it’s widely accepted that TH signaling is regulated at multiple levels. A growing number of discoveries suggest that microRNAs (miRNAs) act as fine-tune regulators of gene expression and adds sophisticated regulatory tiers to signaling pathways. Recently, some pioneering studies in cardiac and skeletal muscle demonstrating the interplay between miRNAs and TH signaling suggest that miRNAs might mediate and/or modulate TH signaling. This review presents recent advances involving the crosstalk between...
原始语种摘要: Thyroid hormone (TH) signaling plays critical roles in the differentiation, growth, metabolism, and physiological function of all organs or tissues, including heart and skeletal muscle. Due to the significant progress in our understanding of the molecular mechanisms that underlie TH action, it’s widely accepted that TH signaling is regulated at multiple levels. A growing number of discoveries suggest that microRNAs (miRNAs) act as fine-tune regulators of gene expression and adds sophisticated regulatory tiers to signaling pathways. Recently, some pioneering studies in cardiac and skeletal muscle demonstrating the interplay between miRNAs and TH signaling suggest that miRNAs might mediate and/or modulate TH signaling. This review presents recent advances involving the crosstalk between...
全文获取路径: Springer  (合作)
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影响因子:3 (2012)

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关键词翻译
关键词翻译
  • signaling 发信号
  • muscle 肌肉
  • hormone 激素
  • skeletal 骨架
  • pathological 病理学的
  • regulatory 控制的
  • understanding 理解
  • suggest 建议
  • thyroid 甲状腺
  • emphasis 强调