Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways
作者: Ya-feng LiGayani NanayakkaraYu SunXinyuan LiLuqiao WangRamon CuetoYing ShaoHangfei FuCandice JohnsonJiali ChengXiongwen ChenWenhui HuJun YuEric T. ChoiHong WangXiao-feng Yang
作者单位: 1Lewis Katz School of Medicine at Temple University
2The Shanxi Provincial People’s Hospital, an Affiliate Hospital of Shanxi Medical University
3Lewis Katz School of Medicine at Temple Univers
刊名: Journal of Hematology & Oncology, 2017, Vol.10 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13045-017-0406-2
关键词: Caspase-1Microarray datasetsMeta-analysisInflammation and transcriptome
英文摘要: It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can significantly impact the transcriptome. However, it is not known whether all the effects exerted by caspase-1 on transcriptome are mediated only by its well-known substrates. Therefore, we hypothesized that the effects of caspase-1 on transcriptome may be partially independent from IL-1β, IL-18, and Sirt-1.
原始语种摘要: It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can significantly impact the transcriptome. However, it is not known whether all the effects exerted by caspase-1 on transcriptome are mediated only by its well-known substrates. Therefore, we hypothesized that the effects of caspase-1 on transcriptome may be partially independent from IL-1β, IL-18, and Sirt-1.
全文获取路径: Springer  (合作)
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影响因子:4.458 (2012)

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关键词翻译
关键词翻译
  • identification 辨认
  • regulated 规定
  • knockout 出模器
  • independent 独立的
  • downstream 顺聊
  • novel 长篇小说
  • various 千变万化的
  • derived 导生的
  • whether 是否
  • significantly 较大地