Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
作者: Anna C. ReisetterMichael J. MuehlbauerJames R. BainMichael NodzenskiRobert D. StevensOlga IlkayevaBoyd E. MetzgerChristopher B. NewgardWilliam L. LoweDenise M. Scholtens
作者单位: 1Northwestern University Feinberg School of Medicine
2Duke University Medical Center
3Duke University School of Medicine
刊名: BMC Bioinformatics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12859-017-1501-7
关键词: MetabolomicsNon-targetedGas chromatography/mass spectrometryGC/MSNormalizationBatch effects
英文摘要: Metabolomics offers a unique integrative perspective for health research, reflecting genetic and environmental contributions to disease-related phenotypes. Identifying robust associations in population-based or large-scale clinical studies demands large numbers of subjects and therefore sample batching for gas-chromatography/mass spectrometry (GC/MS) non-targeted assays. When run over weeks or months, technical noise due to batch and run-order threatens data interpretability. Application of existing normalization methods to metabolomics is challenged by unsatisfied modeling assumptions and, notably, failure to address batch-specific truncation of low abundance compounds.
原始语种摘要: Metabolomics offers a unique integrative perspective for health research, reflecting genetic and environmental contributions to disease-related phenotypes. Identifying robust associations in population-based or large-scale clinical studies demands large numbers of subjects and therefore sample batching for gas-chromatography/mass spectrometry (GC/MS) non-targeted assays. When run over weeks or months, technical noise due to batch and run-order threatens data interpretability. Application of existing normalization methods to metabolomics is challenged by unsatisfied modeling assumptions and, notably, failure to address batch-specific truncation of low abundance compounds.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.024 (2012)

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关键词翻译
关键词翻译
  • normalization 正规化
  • spectrometry 光谱测定
  • chromatography 色层分离法
  • targeted 对准目标的
  • modeling 制祝型
  • truncation 
  • existing 现行
  • batch 一批
  • large 大的
  • robust 牢固的