Aminoglucose-functionalized, redox-responsive polymer nanomicelles for overcoming chemoresistance in lung cancer cells
作者: Yi ZhouHuaying WenLiang GuJijun FuJiayi GuoLingran DuXiaoqin ZhouXiyong YuYugang HuangHe Wang
作者单位: 1Guangzhou Medical University
刊名: Journal of Nanobiotechnology, 2017, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12951-017-0316-z
关键词: Gult-1Redox-responsive polymerNanomicellesMultidrug resistanceCancer therapy
英文摘要: Chemotherapeutic drugs used for cancer therapy frequently encounter multiple-drug resistance (MDR). Nanoscale carriers that can target tumors to accumulate and release drugs intracellularly have the greatest potential for overcoming MDR. Glucose transporter-1 (GLUT-1) and glutathione (GSH) overexpression in cancer cells was exploited to assemble aminoglucose (AG)-conjugated, redox-responsive nanomicelles from a single disulfide bond-bridged block polymer of polyethylene glycol and polylactic acid (AG-PEG-SS-PLA). However, whether this dual functional vector can overcome MDR in lung cancer is unknown.
原始语种摘要: Chemotherapeutic drugs used for cancer therapy frequently encounter multiple-drug resistance (MDR). Nanoscale carriers that can target tumors to accumulate and release drugs intracellularly have the greatest potential for overcoming MDR. Glucose transporter-1 (GLUT-1) and glutathione (GSH) overexpression in cancer cells was exploited to assemble aminoglucose (AG)-conjugated, redox-responsive nanomicelles from a single disulfide bond-bridged block polymer of polyethylene glycol and polylactic acid (AG-PEG-SS-PLA). However, whether this dual functional vector can overcome MDR in lung cancer is unknown.
全文获取路径: Springer  (合作)
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关键词翻译
关键词翻译
  • polymer 聚合物
  • responsive 承担责任
  • bridged 跨接的
  • assemble 集合
  • redox 氧化还原
  • polyethylene 聚乙烯
  • conjugated 共轭的
  • drugs 药品
  • encounter 碰撞
  • glycol 甘醇