Detection of Illegal Abortion-Induced Drugs Using Rapid and Simultaneous Method for the Determination of Abortion-Induced Compounds by LC–MS/MS
作者: Ji Hyun LeeHan Na ParkNam Sook KimHyung-Joon ParkSeongsoo ParkDongwoo ShinHoil Kang
作者单位: 1Division of Advanced Analysis, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety
刊名: Chromatographia, 2019, Vol.82 (9), pp.1365-1371
来源数据库: Springer Journal
DOI: 10.1007/s10337-019-03758-1
关键词: LC–MS/MSCounterfeit drugAbortionValidationScreening
英文摘要: Abstract(#br)With an increase in the number of individuals opting for illegal abortion, the use of counterfeit abortion medicines is increasing throughout the black market. In the present study, a rapid and simultaneous liquid chromatography–tandem mass spectrometry method for detecting abortion-inducing drugs in counterfeit medicines was developed. The parameters used for validating the method using tablet-, powder- and capsule-type matrix-blank samples were limit of detection (0.10–5.00 ng/mL), limit of quantitation (0.31–15.00 ng/mL), linearity ( r 2 > 0.998), recovery of spiked matrix-blank samples (83.1–114.5%), intraday and interday accuracy (86.4–113.5%) and precision (≤ 9.7% RSD) and stability (≤ 13.3% RSD). Seized tablet-type drugs, advertised for their abortion-inducing...
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影响因子:1.437 (2012)

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