The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth
作者: Laura W. BowersClaire G. LinebergerNikki A. FordEmily L. RossiArunima PunjalaKristina K. CampBruce K. KimlerCarol J. FabianStephen D. Hursting
作者单位: 1Department of Nutrition, University of North Carolina
2Lineberger Comprehensive Cancer Center, University of North Carolina
3Department of Nutritional Sciences, University of Texas at Austin
4Department of Radiation Oncology, University of Kansas Medical Center
5Department of Internal Medicine, University of Kansas Medical Center
6Nutrition Research Institute, University of North Carolina
刊名: Breast Cancer Research and Treatment, 2019, Vol.173 (3), pp.545-557
来源数据库: Springer Nature Journal
DOI: 10.1007/s10549-018-5021-6
关键词: Breast cancerSecoisolariciresinol diglucoside (SDG)Plant lignanEnterolactone (ENL)Enterodiol (END)NFκB
原始语种摘要: Abstract(#br) Purpose(#br)Exposure to the polyphenolic plant lignan secoisolariciresinol diglucoside (SDG) and its metabolite enterolactone (ENL) has been associated with reduced breast cancer progression, particularly for estrogen receptor alpha (ERα)-negative disease, and decreased preclinical mammary tumor growth. However, while preclinical studies have established that SDG and ENL affect measures of progression in models of triple-negative breast cancer (TNBC, a subset of ERα-negative disease), the molecular mechanisms underlying these effects remain unclear.(#br) Methods(#br)C57BL/6 mice were fed a control diet (control, 10% kcal from fat) or control diet + SDG (SDG, 100 mg/kg diet) for 8 weeks, then orthotopically injected with syngeneic E0771 mammary tumor cells (a model of TNBC);...
全文获取路径: Springer Nature  (合作)
影响因子:4.469 (2012)