Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal
作者: Aminata MbayeAmy GayeBaba DieyeYaye D. NdiayeAmy K. BeiMuna AffaraAwa B. DemeMamadou S. YadeKhadim DiongueIbrahima M. NdiayeTolla NdiayeMouhamed SyNgayo SyOusmane KoitaDonald J. KrogstadSarah VolkmanDavis NwakanmaDaouda Ndiaye
作者单位: 1Cheikh Anta Diop University of Dakar
2Harvard School of Public Health
3Medical Research Council Unit, The Gambia
4University of Bamako
5Tulane University
刊名: Malaria Journal, 2017, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12936-017-1897-6
关键词: ChemosensitivityGenotypingPlasmodium falciparumPikine
英文摘要: The monitoring of Plasmodium falciparum sensitivity to anti-malarial drugs is a necessity for effective case management of malaria. This species is characterized by a strong resistance to anti-malarial drugs. In Senegal, the first cases of chloroquine resistance were reported in the Dakar region in 1988 with nearly 7% population prevalence, reaching 47% by 1990. It is in this context that sulfadoxine–pyrimethamine temporarily replaced chloroquine as first line treatment in 2003, pending the introduction of artemisinin-based combination therapy in 2006. The purpose of this study is to assess the ex vivo sensitivity to different anti-malarial drugs of the P. falciparum population from Pikine.
原始语种摘要: The monitoring of Plasmodium falciparum sensitivity to anti-malarial drugs is a necessity for effective case management of malaria. This species is characterized by a strong resistance to anti-malarial drugs. In Senegal, the first cases of chloroquine resistance were reported in the Dakar region in 1988 with nearly 7% population prevalence, reaching 47% by 1990. It is in this context that sulfadoxine–pyrimethamine temporarily replaced chloroquine as first line treatment in 2003, pending the introduction of artemisinin-based combination therapy in 2006. The purpose of this study is to assess the ex vivo sensitivity to different anti-malarial drugs of the P. falciparum population from Pikine.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.4 (2012)

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关键词翻译
关键词翻译
  • susceptibility 磁化率
  • malarial 疟疾的
  • chloroquine 氯奎
  • sulfadoxine 磺胺多辛
  • pyrimethamine 乙嘧啶
  • isolates 单离体
  • necessity 必要性
  • drugs 药品
  • population 母体
  • temporarily 暂时地