Rs4878104 contributes to Alzheimer’s disease risk and regulates DAPK1 gene expression
作者: Yang HuLiang ChengYing ZhangWeiyang BaiWenyang ZhouTao WangZhifa HanJian ZongShuilin JinJun ZhangQinghua JiangGuiyou Liu
作者单位: 1Harbin Institute of Technology
2Heilongjiang Province Land Reclamation Headquarters General Hospital
刊名: Neurological Sciences, 2017, Vol.38 (7), pp.1255-1262
来源数据库: Springer Journal
DOI: 10.1007/s10072-017-2959-9
关键词: Alzheimer’s diseaseDAPK1Rs4878104Gene expressionExpression quantitative trait loci
英文摘要: In 2006, a candidate gene study reported death-associated protein kinase 1 (DAPK1) rs4878104 variant to be significantly associated with Alzheimer’s disease (AD) risk. However, the following studies showed inconsistent association results. Here, we conducted an updated analysis to investigate the potential association between rs4878104 and AD using a total of 60,751 samples (20,161 AD cases and 40,590 controls). In the pooled population, the results based on the allele and genotype genetic models show that rs4878104 variant is not significantly associated with AD risk. Interestingly, we identified rs4878104 variant to be significantly associated with AD risk in American population and Chinese population in subgroup analysis. Using multiple large-scale expression quantitative trait loci...
原始语种摘要: In 2006, a candidate gene study reported death-associated protein kinase 1 (DAPK1) rs4878104 variant to be significantly associated with Alzheimer’s disease (AD) risk. However, the following studies showed inconsistent association results. Here, we conducted an updated analysis to investigate the potential association between rs4878104 and AD using a total of 60,751 samples (20,161 AD cases and 40,590 controls). In the pooled population, the results based on the allele and genotype genetic models show that rs4878104 variant is not significantly associated with AD risk. Interestingly, we identified rs4878104 variant to be significantly associated with AD risk in American population and Chinese population in subgroup analysis. Using multiple large-scale expression quantitative trait loci...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:1.412 (2012)

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关键词翻译
关键词翻译
  • expression 表示
  • population 母体
  • trait 性状
  • modifying 修改
  • genetic 遗传的
  • investigate 
  • quantitative 量的
  • associated 相关的
  • association 联合
  • significantly 较大地