Design and evaluation of dual CD44 receptor and folate receptor-targeting double-smart pH-response multifunctional nanocarrier
作者: Daquan ChenXiaoyan SongKaili WangChunjing GuoYueming YuHuaying FanFeng Zhao
作者单位: 1Yantai University
2State Key Laboratory of Long-acting and Targeting Drug Delivery System
刊名: Journal of Nanoparticle Research, 2017, Vol.19 (12)
来源数据库: Springer Journal
DOI: 10.1007/s11051-017-4076-3
关键词: CD44 receptor and folate receptor dual targetingDouble pH-sensitivityOligosaccharides of hyaluronan (oHA) conjugatesDrug deliveryCurcumin nanoparticles
英文摘要: In this article, in order to enhance the bioavailiability and tumor targeting of curcumin (Cur), the oligosaccharides of hyaluronan conjugates, folic acid-oligosaccharides of hyaluronan-acetal-menthone 1,2-glycerol ketal (FA-oHA-Ace-MGK) carried oHA as a ligand to CD44 receptor, double-pH-sensitive Ace-MGK as hydrophobic moieties, and FA as the target of folate receptor. The structure characteristics of this smart response multifunctional dual-targeting nano-sized carrier was measured by fourier-transform infrared (FT-IR) and nuclear magnetic resonance (1H–NMR). Cur, an anticancer drug, was successfully loaded in FA-oHA-Ace-MGK micelles by self-assembly. The measurement results of transmission electron microscopy (TEM) presented that the Cur-loaded micelles were spherical in...
原始语种摘要: In this article, in order to enhance the bioavailiability and tumor targeting of curcumin (Cur), the oligosaccharides of hyaluronan conjugates, folic acid-oligosaccharides of hyaluronan-acetal-menthone 1,2-glycerol ketal (FA-oHA-Ace-MGK) carried oHA as a ligand to CD44 receptor, double-pH-sensitive Ace-MGK as hydrophobic moieties, and FA as the target of folate receptor. The structure characteristics of this smart response multifunctional dual-targeting nano-sized carrier was measured by fourier-transform infrared (FT-IR) and nuclear magnetic resonance (1H–NMR). Cur, an anticancer drug, was successfully loaded in FA-oHA-Ace-MGK micelles by self-assembly. The measurement results of transmission electron microscopy (TEM) presented that the Cur-loaded micelles were spherical in...
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:2.175 (2012)

×
关键词翻译
关键词翻译
  • targeting 导向目标
  • receptor 接受体
  • folate 叶酸盐
  • loaded 加负荷的
  • response 响应
  • potential 
  • conjugates 接合藻类
  • menthone 薄荷酮
  • smart 修]灵巧[便,敏
  • anticancer 抗癌的