Medical history of chemotherapy or immunosuppressive drug treatment and risk of amyotrophic lateral sclerosis (ALS)
作者: Thomas KuczmarskiElijah W. StommelKristen RileyRup TandanVinay ChaudhryLora ClawsonTracie A. CallerPatricia L. HeneganDominic N. FacciponteWalter G. BradleyAngeline S. Andrew
作者单位: 1Dartmouth-Hitchcock Medical Center
2Johns Hopkins University
3University of Vermont Medical Center
4Cheyenne Regional Medical Center, Medical Specialty Clinic
5University of Miami
刊名: Journal of Neurology, 2017, Vol.264 (8), pp.1763-1767
来源数据库: Springer Journal
DOI: 10.1007/s00415-017-8564-2
关键词: Amyotrophic lateral sclerosisCase–controlChemotherapyImmunosuppressantNeurodegenerative
英文摘要: A recent population-based analysis demonstrated lower risk of the lethal degenerative neuromuscular disease, amyotrophic lateral sclerosis (ALS) associated with history of the use of ‘antineoplastic agents’ and ‘immunosuppressants’. To see if this finding was generalizable to other ALS cohorts, we examined associations between use of these agents and ALS risk in an independent case–control study of n = 414 ALS patients and n = 361 controls in an Eastern US population. Controls were sampled from the general population and among non-neurodegenerative disease patients. A history of chemotherapy treatment was significantly associated with a decreased ALS risk (OR 0.46, 95% CI 0.22–0.89, P = 0.026). We did not observe an association between risk of ALS and immunosuppressant therapy use (OR...
原始语种摘要: A recent population-based analysis demonstrated lower risk of the lethal degenerative neuromuscular disease, amyotrophic lateral sclerosis (ALS) associated with history of the use of ‘antineoplastic agents’ and ‘immunosuppressants’. To see if this finding was generalizable to other ALS cohorts, we examined associations between use of these agents and ALS risk in an independent case–control study of n = 414 ALS patients and n = 361 controls in an Eastern US population. Controls were sampled from the general population and among non-neurodegenerative disease patients. A history of chemotherapy treatment was significantly associated with a decreased ALS risk (OR 0.46, 95% CI 0.22–0.89, P = 0.026). We did not observe an association between risk of ALS and immunosuppressant therapy use (OR...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.578 (2012)

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关键词翻译
关键词翻译
  • ALS Accumulator Left Shift
  • chemotherapy 化学疗法
  • sclerosis 硬化
  • amyotrophic 肌肉萎缩的
  • lateral 侧面的
  • treatment 处理
  • history 历史
  • controls 控制机构
  • degenerative 退化的
  • gender 性别