Transcriptome-wide N 6 -methyladenosine methylome profiling of porcine muscle and adipose tissues reveals a potential mechanism for transcriptional regulation and differential methylation pattern
作者: Xuelian TaoJianning ChenYanzhi JiangYingying WeiYan ChenHuaming XuLi ZhuGuoqing TangMingzhou LiAnan JiangSurong ShuaiLin BaiHaifeng LiuJideng MaLong JinAnxiang WenQin WangGuangxiang ZhuMeng XieJiayun WuTao HeChunyu HuangXiang GaoXuewei Li
作者单位: 1Sichuan Agricultural University
2Genergy Biological Technology (Shanghai) Company of Limited Liability
刊名: BMC Genomics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12864-017-3719-1
关键词: Differentially methylated genesMeRIP-SeqN 6-methyladenosinePorcineTranscriptional regulation
英文摘要: N 6 -methyladenosine (m6A) is the most prevalent internal form of modification in messenger RNA in higher eukaryotes and potential regulatory functions of reversible m6A methylation on mRNA have been revealed by mapping of m6A methylomes in several species. m6A modification in active gene regulation manifests itself as altered methylation profiles in a tissue-specific manner or in response to changing cellular or species living environment. However, up to date, there has no data on m6A porcine transcriptome-wide map and its potential biological roles in adipose deposition and muscle growth.
原始语种摘要: N 6 -methyladenosine (m6A) is the most prevalent internal form of modification in messenger RNA in higher eukaryotes and potential regulatory functions of reversible m6A methylation on mRNA have been revealed by mapping of m6A methylomes in several species. m6A modification in active gene regulation manifests itself as altered methylation profiles in a tissue-specific manner or in response to changing cellular or species living environment. However, up to date, there has no data on m6A porcine transcriptome-wide map and its potential biological roles in adipose deposition and muscle growth.
全文获取路径: Springer  (合作)
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影响因子:4.397 (2012)

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关键词翻译
关键词翻译
  • potential 
  • adipose 脂肪的
  • regulation 
  • muscle 肌肉
  • methylation 甲基化酌
  • mechanism 机构
  • mRNA m核糖核酸
  • porcine 猪的
  • biological 生物学的
  • methylated 甲基化了的