Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study
作者: Geetha ChittoorKarin HaackNitesh R. MehtaSandra LastonShelley A. ColeAnthony G. ComuzzieNancy F. ButteV. Saroja Voruganti
作者单位: 1University of North Carolina at Chapel Hill
2Texas Biomedical Research Institute
3Baylor College of Medicine
4University of Texas Rio Grande Valley
刊名: BMC Medical Genetics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12881-016-0366-3
关键词: Uric acid clearanceGenetic variationFractional excretion of uric acidHispanic children
英文摘要: Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study.
原始语种摘要: Reduced renal excretion of uric acid plays a significant role in the development of hyperuricemia and gout in adults. Hyperuricemia has been associated with chronic kidney disease and cardiovascular disease in children and adults. There are limited genome-wide association studies associating genetic polymorphisms with renal urate excretion measures. Therefore, we investigated the genetic factors that influence the excretion of uric acid and related indices in 768 Hispanic children of the Viva La Familia Study.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.536 (2012)

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关键词翻译
关键词翻译
  • excretion 分泌
  • renal 肾的
  • variation 变异
  • children 子女
  • hyperuricemia 血尿酸过多
  • urate 尿酸盐
  • clearance 间隙
  • underlying 下伏的
  • associating 缔合
  • genetic 遗传的