Factors affecting interactome-based prediction of human genes associated with clinical signs
作者: Sara González-PérezFlorencio PazosMónica Chagoyen
作者单位: 1Computational Systems Biology Group, National Center for Biotechnology (CNB-CSIC)
刊名: BMC Bioinformatics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12859-017-1754-1
关键词: Gene prioritizationHuman interactomeClinical signsNetwork-based methods
英文摘要: Clinical signs are a fundamental aspect of human pathologies. While disease diagnosis is problematic or impossible in many cases, signs are easier to perceive and categorize. Clinical signs are increasingly used, together with molecular networks, to prioritize detected variants in clinical genomics pipelines, even if the patient is still undiagnosed. Here we analyze the ability of these network-based methods to predict genes that underlie clinical signs from the human interactome.
原始语种摘要: Clinical signs are a fundamental aspect of human pathologies. While disease diagnosis is problematic or impossible in many cases, signs are easier to perceive and categorize. Clinical signs are increasingly used, together with molecular networks, to prioritize detected variants in clinical genomics pipelines, even if the patient is still undiagnosed. Here we analyze the ability of these network-based methods to predict genes that underlie clinical signs from the human interactome.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.024 (2012)

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关键词翻译
关键词翻译
  • based 基于
  • categorize 分类
  • impossible 不可能的
  • human 人的
  • perceive 感觉
  • still 
  • prediction 预报
  • fundamental 基本的
  • clinical 临床的
  • affecting 令人感动的