Experimental in vitro and in vivo systems for studying the innate immune response during dengue virus infections
作者: Bouchra KitabMichinori KoharaKyoko Tsukiyama-Kohara
作者单位: 1Joint Faculty of Veterinary Medicine, Kagoshima University
2Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science
刊名: Archives of Virology, 2018, Vol.163 (7), pp.1717-1726
来源数据库: Springer Nature Journal
DOI: 10.1007/s00705-018-3784-z
英文摘要: Abstract(#br)Dengue is the most prevalent arboviral disease in humans and leads to significant morbidity and socioeconomic burden in tropical and subtropical areas. Dengue is caused by infection with any of the four closely related serotypes of dengue virus (DENV1-4) and usually manifests as a mild febrile illness, but may develop into fatal dengue hemorrhagic fever and shock syndrome. There are no specific antiviral therapies against dengue because understanding of DENV biology is limited. A tetravalent chimeric dengue vaccine, Dengvaxia, has finally been licensed for use, but its efficacy was significantly lower against DENV-2 infections and in dengue-naïve individuals. The identification of mechanisms underlying the interactions between DENV and immune responses will help to determine...
全文获取路径: Springer Nature  (合作)
影响因子:2.03 (2012)