A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture
作者: Justin CaccavaleDavid FiumaraMichael StapfLiedeke SweitzerHannah J. AndersonJonathan GorkyPrasad DhurjatiDeni S. Galileo
作者单位: 1University of Delaware
2Thomas Jefferson University
3Christiana Care Health System
刊名: BMC Systems Biology, 2017, Vol.11 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12918-017-0516-z
关键词: Rule-based modelGlioblastomaCell motilityScratch assayL1CAMNetLogo2-DCell cultureCancerBiological modeling framework
英文摘要: Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tissue. Simple 2-dimensional laboratory assays (e.g., a scratch assay) commonly are used to measure the effects of various experimental perturbations, such as treatment with chemical inhibitors. Several mathematical models have been developed to aid the understanding of the motile behavior and proliferation of GBM cells. However, many are mathematically complicated, look at multiple interdependent phenomena, and/or use modeling software not freely available to the research community. These attributes make the adoption of models and simulations of even simple 2-dimensional cell behavior...
原始语种摘要: Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tissue. Simple 2-dimensional laboratory assays (e.g., a scratch assay) commonly are used to measure the effects of various experimental perturbations, such as treatment with chemical inhibitors. Several mathematical models have been developed to aid the understanding of the motile behavior and proliferation of GBM cells. However, many are mathematically complicated, look at multiple interdependent phenomena, and/or use modeling software not freely available to the research community. These attributes make the adoption of models and simulations of even simple 2-dimensional cell behavior...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.982 (2012)

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关键词翻译
关键词翻译
  • modeling 制祝型
  • framework 构架
  • accurate 精确的
  • simple 单纯的
  • CAM 计算机辅助制造
  • community 群落
  • simulation 模拟
  • motility 游动性
  • phenomena 现象
  • culture