Circular RNAs in cancer: an emerging key player
作者: Yeping DongDan HeZhenzi PengWei PengWenwen ShiJun WangBin LiChunfang ZhangChaojun Duan
作者单位: 1Central South University
刊名: Journal of Hematology & Oncology, 2017, Vol.10 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13045-016-0370-2
关键词: Circular RNAsCancerMicroRNA spongesBiomarkers
英文摘要: Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, subsequent research shows that circRNAs can function as microRNA (miRNA) sponges and regulate splicing and transcription. Emerging evidence shows that circRNAs possess closely associated with human diseases, especially cancers, and may serve as better biomarkers. After miRNA and long noncoding RNA (lncRNA), circRNAs are becoming a new hotspot in the field of RNA of cancer. Here, we review biogenesis and metabolism of circRNAs, their functions, and potential roles...
原始语种摘要: Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, subsequent research shows that circRNAs can function as microRNA (miRNA) sponges and regulate splicing and transcription. Emerging evidence shows that circRNAs possess closely associated with human diseases, especially cancers, and may serve as better biomarkers. After miRNA and long noncoding RNA (lncRNA), circRNAs are becoming a new hotspot in the field of RNA of cancer. Here, we review biogenesis and metabolism of circRNAs, their functions, and potential roles...
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影响因子:4.458 (2012)

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关键词翻译
关键词翻译
  • RNA ROYAL NEPAL AIRLINES CORP.
  • splicing 接合
  • transcription 地名转写
  • cancer 癌症
  • mammalian 哺乳动物
  • biogenesis 生源说
  • potential 
  • extensively 广泛地
  • player 局中人
  • expression 表示