Long-term safety of umbilical cord mesenchymal stem cells transplantation for systemic lupus erythematosus: a 6-year follow-up study
作者: Dandan WangLingying NiuXuebing FengXinran YuanShengnan ZhaoHuayong ZhangJun LiangCheng ZhaoHong WangBingzhu HuaLingyun Sun
作者单位: 1The Affiliated Drum Tower Hospital of Nanjing University Medical School
刊名: Clinical and Experimental Medicine, 2017, Vol.17 (3), pp.333-340
来源数据库: Springer Journal
DOI: 10.1007/s10238-016-0427-0
关键词: Mesenchymal stem cellsUmbilical cordSystemic lupus erythematosusSafety
英文摘要: The aim of this study is to assess the long-term safety of allogeneic umbilical cord mesenchymal stem cells (UC MSCs) transplantation for patients with refractory systemic lupus erythematosus (SLE). Nine SLE patients, who were refractory to steroid and immunosuppressive drugs treatment and underwent MSCs transplantation in 2009, were enrolled. One million allogeneic UC MSCs per kilogram of body weight were infused intravenously at days 0 and 7. The possible adverse events, including immediately after MSCs infusions, as well as the long-term safety profiles were observed. Blood and urine routine test, liver function, electrocardiogram, chest radiography and serum levels of tumor markers, including alpha fetal protein (AFP), cancer embryo antigen (CEA), carbohydrate antigen 155 (CA155) and...
原始语种摘要: The aim of this study is to assess the long-term safety of allogeneic umbilical cord mesenchymal stem cells (UC MSCs) transplantation for patients with refractory systemic lupus erythematosus (SLE). Nine SLE patients, who were refractory to steroid and immunosuppressive drugs treatment and underwent MSCs transplantation in 2009, were enrolled. One million allogeneic UC MSCs per kilogram of body weight were infused intravenously at days 0 and 7. The possible adverse events, including immediately after MSCs infusions, as well as the long-term safety profiles were observed. Blood and urine routine test, liver function, electrocardiogram, chest radiography and serum levels of tumor markers, including alpha fetal protein (AFP), cancer embryo antigen (CEA), carbohydrate antigen 155 (CA155) and...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.397 (2012)

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关键词翻译
关键词翻译
  • lupus 豺狼座
  • systemic 系统的
  • umbilical 供应脐带
  • mesenchymal 间叶细胞的
  • SLE 全身性红斑狼疮
  • safety 安全
  • bilirubin 胆红素
  • events 定时
  • cells 麻风细胞
  • chest 胸膛