A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model
作者: Shih-Hsin TuYi-Chen HsiehLi-Chi HuangChun-Yu LinKai-Wen HsuWen-Shyang HsiehWei-Ming ChiChia-Hwa Lee
作者单位: 1Taipei Medical University
2Cathay General Hospital
3Breast Medical Center, Taipei Medical University Hospital
4Taipei Cancer Center, Taipei Medical University
5Comprehensive Cancer Center of Taipei Medical University
6Institute of Bioinformatics and Systems Biology, National Chiao Tung University
7China Medical University
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12885-017-3419-x
关键词: Cancer metastasisCirculating tumor cellsQuantitative PCRIn vivo bioluminescent imaging system
英文摘要: As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Both therapeutic target identification and proof-of-concept experimentation in anti-cancer drug development require appropriate animal models, such as xenograft tumor transplantation in transgenic and knockout mice. In the progression of cancer metastasis, circulating tumor cells (CTCs) are the most critical factor in determining the prognosis of cancer patients. Several studies have demonstrated that measuring CTC-specific markers in a clinical setting (e.g., flow cytometry) can provide a current status of cancer development in patients. However, this useful technique has rarely been...
原始语种摘要: As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Both therapeutic target identification and proof-of-concept experimentation in anti-cancer drug development require appropriate animal models, such as xenograft tumor transplantation in transgenic and knockout mice. In the progression of cancer metastasis, circulating tumor cells (CTCs) are the most critical factor in determining the prognosis of cancer patients. Several studies have demonstrated that measuring CTC-specific markers in a clinical setting (e.g., flow cytometry) can provide a current status of cancer development in patients. However, this useful technique has rarely been...
全文获取路径: Springer  (合作)
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影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • preclinical 临证前期的
  • cells 麻风细胞
  • animal 动物的
  • tumor 肿胀
  • metastasis 同质蜕变
  • human 人的
  • prognosis 预报
  • cancer 癌症
  • therapeutic 治疗的
  • underlying 下伏的