Metabolomics approaches in pancreatic adenocarcinoma: tumor metabolism profiling predicts clinical outcome of patients
作者: S. BattiniF. FaitotA. ImperialeA. E. CicekC. HeimburgerG. AverousP. BachellierI. J. Namer
作者单位: 1ICube, UMR 7357 University of Strasbourg/CNRS
2University Hospitals of Strasbourg
3FMTS, Faculty of Medicine
4Carnegie Mellon University
5Bilkent University
刊名: BMC Medicine, 2017, Vol.15 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12916-017-0810-z
关键词: MetabolomicsHRMASNMRBiomarkerPancreatic adenocarcinomaLong-term survival
英文摘要: Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study were to (1) describe the metabolome of pancreatic parenchyma (PP) and PA, (2) determine the impact of neoadjuvant chemotherapy on PP and PA, and (3) find tissue metabolic biomarkers associated with long-term survivors, using metabolomics analysis.
原始语种摘要: Pancreatic adenocarcinomas (PAs) have very poor prognoses even when surgery is possible. Currently, there are no tissular biomarkers to predict long-term survival in patients with PA. The aims of this study were to (1) describe the metabolome of pancreatic parenchyma (PP) and PA, (2) determine the impact of neoadjuvant chemotherapy on PP and PA, and (3) find tissue metabolic biomarkers associated with long-term survivors, using metabolomics analysis.
全文获取路径: Springer  (合作)
分享到:
来源刊物:
影响因子:6.679 (2012)

×
关键词翻译
关键词翻译
  • adenocarcinoma 腺癌
  • pancreatic 胰的
  • survival 生存
  • outcome 效果
  • metabolism 代谢
  • chemotherapy 化学疗法
  • tissular 组织的
  • parenchyma 柔组织
  • tumor 肿胀
  • profiling 仿形切削