The gene–treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry
作者: Akiko SumiUdai NakamuraMasanori IwaseHiroki FujiiToshiaki OhkumaHitoshi IdeTamaki Jodai-KitamuraYuji KomoritaMasahito YoshinariYoichiro HirakawaAtsushi HiranoMichiaki KuboTakanari Kitazono
作者单位: 1Kyushu University
2Diabetes Center, Hakujyuji Hospital
3Centre for Cohort Studies, Graduate School of Medical Sciences Kyushu University
4The George Institute for Global Health University of Sydney
5Kyushu Dental University
6Center for Integrative Medical Sciences, RIKEN
刊名: BMC Medical Genetics, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12881-017-0509-1
关键词: Gene–treatment interactionPON1 Q192R polymorphismStatin therapyInsulin secretion
英文摘要: Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins’ interaction with paraoxonase (PON)1 enzyme polymorphism.
原始语种摘要: Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins’ interaction with paraoxonase (PON)1 enzyme polymorphism.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.536 (2012)

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关键词翻译
关键词翻译
  • paraoxonase 二乙基对硝基苯磷酸酯酶
  • registry 注册
  • diabetes 糖尿病
  • insulin 胰岛素
  • secretion 分泌
  • glucose 葡萄糖
  • Japanese 日本人日语日本的
  • interaction 相互酌
  • treatment 处理
  • polymorphism 多晶形