Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms
作者: Nadia CattaneRoberta RossiMariangela LanfrediAnnamaria Cattaneo
作者单位: 1IRCCS Istituto Centro San Giovanni di Dio - Fatebenefratelli
2Institute of Psychiatry, King’s College London
3Institute of Psychiatry, Psychology and Neuroscience, King’s College London
刊名: BMC Psychiatry, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12888-017-1383-2
关键词: Borderline personality disorderChildhood traumaHPA axisEndogenous opioid systemNeurotransmissionNeuroplasticityNeuroimaging studiesEpigenetic mechanisms
英文摘要: According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability.
原始语种摘要: According to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.233 (2012)

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关键词翻译
关键词翻译
  • biological 生物学的
  • trauma 外伤
  • disorder 无序
  • personality 人格
  • childhood 幼年
  • epigenetic 后成的
  • effects 海员自身物品
  • vulnerability 脆弱性
  • opioid 鸦片样物质
  • several 各自