Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity
作者: Wei-Xing ZhaoJun-Han ZhangJiang-Bei CaoWei WangDong-Xin WangXiao-Ying ZhangJun YuYong-Yi ZhangYou-Zhi ZhangWei-Dong Mi
作者单位: 1Chinese PLA General Hospital
2Central South University
3The General Hospital of the PLA Rocket Force
4Peking University First Hospital
5Beijing Key laboratory of Neuropsychopharmacology
刊名: Journal of Neuroinflammation, 2017, Vol.14 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12974-016-0781-6
关键词: AcetaminophenNeuroprotective therapyAntioxidant activityOxidative stressNeuroinflammationMemory impairmentApoptosis
英文摘要: Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) and other progressive neurodegenerative disorders. Increasing evidence suggests that acetaminophen (APAP) has unappreciated antioxidant and anti-inflammatory properties. However, the impact of APAP on the cognitive sequelae of inflammatory and oxidative stress is unknown. The objective of this study is to explore whether APAP could have neuroprotective effects on lipopolysaccharide (LPS)-induced cognitive impairment in mice.
原始语种摘要: Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) and other progressive neurodegenerative disorders. Increasing evidence suggests that acetaminophen (APAP) has unappreciated antioxidant and anti-inflammatory properties. However, the impact of APAP on the cognitive sequelae of inflammatory and oxidative stress is unknown. The objective of this study is to explore whether APAP could have neuroprotective effects on lipopolysaccharide (LPS)-induced cognitive impairment in mice.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:4.351 (2012)

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关键词翻译
关键词翻译
  • impairment 减损
  • induced 感应的
  • antioxidant 抗氧化剂
  • cognitive 修]认知[识
  • activity 活度
  • unappreciated 未得到欣赏的
  • inflammatory 激怒的
  • sequelae 后遗症
  • oxidative 氧化的
  • stress 应力