The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
作者: Pingting ZhouBo LiFurao LiuMeichao ZhangQian WangYuanhua LiuYuan YaoDong Li
作者单位: 1Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine
2Changzheng Hospital, Second Military Medical University
3Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province
刊名: Molecular Cancer, 2017, Vol.16 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12943-017-0624-9
关键词: Pancreatic cancerCancer stem cellEpithelial-to-mesenchymal transitionResistance
英文摘要: The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer...
原始语种摘要: The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer...
全文获取路径: Springer  (合作)
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影响因子:5.134 (2012)

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关键词翻译
关键词翻译
  • transition 转移
  • EMT EMergency Treatment
  • pancreatic 胰的
  • mesenchymal 间叶细胞的
  • treatment 处理
  • cells 麻风细胞
  • cancer 癌症
  • epithelial 上皮的
  • resistance 抵抗
  • implication 蕴涵