Identification of TWIST -interacting genes in prostate cancer
作者: Peng LyuShu-Dong ZhangHiu-Fung YuenCian M. McCruddenQing WenKwok-Wah ChanHang Fai Kwok
作者单位: 1University of Macau
2Ulster University
3Agency for Science, Technology and Research
4Queen’s University of Belfast
5Queen’s University Belfast
6University of Hong Kong
刊名: Science China Life Sciences, 2017, Vol.60 (4), pp.386-396
来源数据库: Springer Journal
DOI: 10.1007/s11427-016-0262-6
关键词: Prostate cancerTWISTPrognostic marker
英文摘要: Prostate cancer is one of the most common cancers in men worldwide, and the number of diagnosed patients has dramatically increased in recent years. Currently, the clinical parameters used to diagnose prostate cancer, such as Gleason score, pathological tumor staging, and prostate-specific antigen (PSA) expression level, are considered insufficient to inform recommendation to guide clinical practice. Thus, identification of a novel biomarker is necessary. TWIST is one of the well-studied targets and is correlated with cancer invasion and metastasis in several human cancers. We have investigated two largest prostate cancer patient cohorts available in GEO database and found that TWIST expression is positive correlated with Gleason score and associated with poorer survival. By using a...
原始语种摘要: Prostate cancer is one of the most common cancers in men worldwide, and the number of diagnosed patients has dramatically increased in recent years. Currently, the clinical parameters used to diagnose prostate cancer, such as Gleason score, pathological tumor staging, and prostate-specific antigen (PSA) expression level, are considered insufficient to inform recommendation to guide clinical practice. Thus, identification of a novel biomarker is necessary. TWIST is one of the well-studied targets and is correlated with cancer invasion and metastasis in several human cancers. We have investigated two largest prostate cancer patient cohorts available in GEO database and found that TWIST expression is positive correlated with Gleason score and associated with poorer survival. By using a...
全文获取路径: Springer  (合作)
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影响因子:2.024 (2011)

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关键词翻译
关键词翻译
  • interacting 相克的
  • prostate 前列腺
  • expression 表示
  • marker 标试器
  • cancer 癌症
  • downstream 顺聊
  • available 可供应的
  • several 各自
  • confirmed 已确认的
  • eight