Intranasal Delivery of a Caspase-1 Inhibitor in the Treatment of Global Cerebral Ischemia
作者: Ningjun ZhaoXiaoying ZhuoYujiao LuYan DongMohammad Ejaz AhmedDonovan TuckerErin L. ScottQuanguang Zhang
作者单位: 1The Affiliated Hospital of Xuzhou Medical University
2Augusta University
刊名: Molecular Neurobiology, 2017, Vol.54 (7), pp.4936-4952
来源数据库: Springer Nature Journal
DOI: 10.1007/s12035-016-0034-9
关键词: Cardiac arrestMitochondriaGliosisNeuroprotectionFunctional improvements
英文摘要: Caspase-1 is an enzyme implicated in neuroinflammation, a critical component of many diseases that affect neuronal degeneration. However, it is unknown whether a caspase-1 inhibitor can modify apoptotic neuronal damage incurred during transient global cerebral ischemia (GCI) and whether intranasal administration of a caspase-1 inhibitor is an effective treatment following GCI. The present study was conducted to examine the potential efficiency of post-ischemic intranasal administration of the caspase-1 inhibitor Boc-D-CMK in a 4-vessel occlusion model of GCI in the rat. Herein, we show that intranasal Boc-D-CMK readily penetrated the central nervous system, subsequently inhibiting caspase-1 activity, decreasing mitochondrial dysfunction, and attenuating caspase-3-dependent apoptotic...
原始语种摘要: Caspase-1 is an enzyme implicated in neuroinflammation, a critical component of many diseases that affect neuronal degeneration. However, it is unknown whether a caspase-1 inhibitor can modify apoptotic neuronal damage incurred during transient global cerebral ischemia (GCI) and whether intranasal administration of a caspase-1 inhibitor is an effective treatment following GCI. The present study was conducted to examine the potential efficiency of post-ischemic intranasal administration of the caspase-1 inhibitor Boc-D-CMK in a 4-vessel occlusion model of GCI in the rat. Herein, we show that intranasal Boc-D-CMK readily penetrated the central nervous system, subsequently inhibiting caspase-1 activity, decreasing mitochondrial dysfunction, and attenuating caspase-3-dependent apoptotic...
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:5.471 (2012)

×
关键词翻译
关键词翻译
  • 衰减 要害
  • intranasal 鼻内的
  • attenuating 衰减的
  • inhibition 抑制
  • administration 管理
  • neuronal 二乙基溴乙酰胺
  • inflammatory 激怒的
  • vulnerable 要害
  • attenuate 要害
  • inhibitor 抑制剂
  • transient 瞬变现象