Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models
作者: Jing YuanYan ShenXia YangYing XieXin LinWen ZengYingting ZhaoMaolu TianYan Zha
作者单位: 1Department of Nephrology Guizhou Provincial People’s Hospital
刊名: BMC Nephrology, 2017, Vol.18 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12882-017-0708-1
关键词: Thymosin β4Transforming growth factorβRenal fibrosisCell apoptosis
英文摘要: Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine the effects of Tβ4 on the renal apoptosis and the expression of transforming growth factor (TGF-β), E-cadherin, and α-smooth muscle actin (α-SMA) in CRTIF rat models.
原始语种摘要: Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine the effects of Tβ4 on the renal apoptosis and the expression of transforming growth factor (TGF-β), E-cadherin, and α-smooth muscle actin (α-SMA) in CRTIF rat models.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:1.644 (2012)

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关键词翻译
关键词翻译
  • fibrosis 纤维化
  • tubular 管状的
  • renal 肾的
  • apoptosis 细胞死
  • inhibition 抑制
  • pathway 轨道
  • inflammation 炎症
  • interstitial 间隙原子
  • factor 因素
  • growth 生长