An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity
作者: Ruoxi LiuXueling YuanJing YuQi QuanHaoye MengCheng WangAiyuan WangQuanyi GuoJiang PengShibi Lu
作者单位: 1Chinese PLA General Hospital
2Yokohama University of Pharmacy
刊名: Journal of Orthopaedic Surgery and Research, 2017, Vol.12 (1)
来源数据库: Springer Journal
DOI: 10.1186/s13018-017-0647-3
关键词: Aspartic acidOsteoarthritisKneeGenderEthnicityMeta-analysisPolymorphism
英文摘要: Knee osteoarthritis (KOA) is the most prevalent form of knee joint disease and characterized by the progressive degeneration of articular cartilage. Although pathology of KOA remains unknown, genetic factors are considered to be the major cause. Asporin is a group of biologically active components of extracellular matrix (ECM) in articular cartilage, and asporin gene (ASPN) D-repeat polymorphism was reported to be associated with KOA. Thus, our meta-analysis is aimed at investigation of the association between asporin D-repeat polymorphism and susceptibility of KOA.
原始语种摘要: Knee osteoarthritis (KOA) is the most prevalent form of knee joint disease and characterized by the progressive degeneration of articular cartilage. Although pathology of KOA remains unknown, genetic factors are considered to be the major cause. Asporin is a group of biologically active components of extracellular matrix (ECM) in articular cartilage, and asporin gene (ASPN) D-repeat polymorphism was reported to be associated with KOA. Thus, our meta-analysis is aimed at investigation of the association between asporin D-repeat polymorphism and susceptibility of KOA.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:1.013 (2012)

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关键词翻译
关键词翻译
  • osteoarthritis 骨关节炎
  • gender 性别
  • analysis 分析
  • repeat 中继
  • articular 关节的
  • cartilage 软骨
  • joint 节理
  • prevalent 普通
  • susceptibility 磁化率
  • updated 修改