Evolution of the vertebrate insulin receptor substrate ( Irs ) gene family
作者: Ahmad Al-SalamDavid M. Irwin
作者单位: 1University of Toronto
2Banting and Best Diabetes Centre, University of Toronto
刊名: BMC Evolutionary Biology, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12862-017-0994-z
关键词: Insulin receptor substrateGene duplicationProtein evolutionEpisodic evolutionPhylogenyVertebratePseudogene
英文摘要: Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3 , has been pseudogenized in humans. While it is known that the Irs gene family originated in vertebrates, it is not known when it originated and which members are most closely related to each other. A better understanding of the evolution of Irs genes and proteins should provide insight into the regulation of metabolism by insulin.
原始语种摘要: Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3 , has been pseudogenized in humans. While it is known that the Irs gene family originated in vertebrates, it is not known when it originated and which members are most closely related to each other. A better understanding of the evolution of Irs genes and proteins should provide insight into the regulation of metabolism by insulin.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.285 (2012)

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关键词翻译
关键词翻译
  • gene family 基因家族
  • vertebrate 有脊椎的
  • insulin 胰岛素
  • evolution 进化
  • substrate 基质
  • receptor 接受体
  • proteins 蛋白质
  • known 己知
  • downstream 顺聊
  • however 然而