PET imaging study of brown adipose tissue (BAT) activity in mice devoid of receptor for advanced glycation end products (RAGE)
作者: Yu-Shin DingNoeen MalikSebastian MendozaDaniel TuchmanCarmen Hurtado Del PozoRaquel Lopez DiezAnn-Marie Schmidt
作者单位: 1Department of Radiology, New York University School of Medicine
2Department of Psychiatry, New York University School of Medicine
3Diabetes Research Program, Division of Endocrinology, Department of Medicine, New York University School of Medicine
刊名: Journal of Biosciences, 2019, Vol.44 (4), pp.1-9
来源数据库: Springer Journal
DOI: 10.1007/s12038-019-9900-8
关键词: Brown adipose tissue[ 18 F]FDGHigh-fat dietObesityPET/CTRAGE
英文摘要: Abstract(#br)Brown adipose tissue (BAT) is responsible for adaptive thermogenesis. We previously showed that genetic deficiency of receptor for advanced glycation end products (RAGE) prevented the effects of high-fat diet (HFD). This study was to compare BAT activity in RAGE knock out ( Ager −/− , RKO) and wild-type (WT) mice after treated with HFD or LFD. [ 18 F]FDG PET-CT imaging under identical cold-stimulated conditions and mean standard uptake values (SUV mean ), ratio of SUV iBAT /SUV muscle (SUVR, muscle as the reference region) and %ID/g were used for BAT quantification. The results showed that [ 18 F]FDG uptake (e.g., SUVR) in WT-HFD mice was significantly reduced (three-fold) as compared to that in WT-LFD (1.40 ± 0.07 and 4.03 ± 0.38; P = 0.004). In contrast, BAT activity in RKO...
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影响因子:1.759 (2012)

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