A Review About the Drug Delivery from Microsponges
作者: Mariana Volpato JunqueiraMarcos Luciano Bruschi
作者单位: 1Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringa
刊名: AAPS PharmSciTech, 2018, Vol.19 (4), pp.1501-1511
来源数据库: Springer Nature Journal
DOI: 10.1208/s12249-018-0976-5
关键词: Drug deliveryMicrospongesRelease profilePermeationMicroparticulate systems
原始语种摘要: Abstract(#br)Microparticulate drug delivery systems have shown a great interest in the pharmaceutical area. They allow the increase of drug therapeutic efficacy and the reduction of side effects. In this context, microsponges represent a new model of porous polymer microspheres, which allow the entrapment of a wide range of active agents. During the development, it is necessary the characterization of the system and among of the most important tests are the release and permeation profile analysis. They can demonstrate the behavior of drug in a specific site with a particular application condition and are related to therapeutic efficacy. Therefore, this review provides an overview of drug delivery profile from microsponges. Methods for determination of in vitro release and ex vivo...
全文获取路径: Springer Nature  (合作)
影响因子:1.584 (2012)