The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia
作者: Joanna JaworskaMalgorzata Ziemka-NaleczJoanna SypeckaTeresa Zalewska
作者单位: 1Polish Academy of Sciences
刊名: Journal of Neuroinflammation, 2017, Vol.14 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12974-017-0807-8
关键词: Neonatal hypoxia-ischemiaHistone deacetylase inhibitorsSodium butyrateNeuroprotectionMicrogliaAstrocytesCytokinesInflammation
英文摘要: Histone deacetylase inhibitor (HDACi), sodium butyrate (SB), has been shown to be neuroprotective in adult brain injury models. Potential explanation for the inhibitor action involves among others reduced inflammation. We therefore anticipated that SB will provide a suitable option for brain injury in immature animals. The aim of our study was to test the hypothesis that one of the mechanisms of protection afforded by SB after neonatal hypoxia-ischemia is associated with anti-inflammatory action. We examined the effect of SB on the production of inflammatory factors including analysis of the microglial and astrocytic cell response. We also examined the effect of SB on molecular mediators that are crucial for inducing cerebral damage after ischemia (transcription factors, HSP70, as well as...
原始语种摘要: Histone deacetylase inhibitor (HDACi), sodium butyrate (SB), has been shown to be neuroprotective in adult brain injury models. Potential explanation for the inhibitor action involves among others reduced inflammation. We therefore anticipated that SB will provide a suitable option for brain injury in immature animals. The aim of our study was to test the hypothesis that one of the mechanisms of protection afforded by SB after neonatal hypoxia-ischemia is associated with anti-inflammatory action. We examined the effect of SB on the production of inflammatory factors including analysis of the microglial and astrocytic cell response. We also examined the effect of SB on molecular mediators that are crucial for inducing cerebral damage after ischemia (transcription factors, HSP70, as well as...
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影响因子:4.351 (2012)

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关键词翻译
关键词翻译
  • deacetylase 脱乙酰基酶
  • hypoxia 氧过少
  • neonatal 新生儿的
  • butyrate 丁酸酸盐
  • ischemia 局部贫血
  • histone 组蛋白
  • inhibitor 抑制剂
  • potential 
  • brain 
  • sodium