The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C
作者: Caroline ManchieroArielle Karen da Silva NunesMariana Carvalheiro MagriBianca Peixoto DantasCelso Carmo MazzaAntonio Alci BaroneFátima Mitiko Tengan
作者单位: 1School of Medicine, University of São Paulo (Universidade de São Paulo - USP)
2School of Medicine, University of São Paulo
刊名: BMC Infectious Diseases, 2017, Vol.17 (1)
来源数据库: Springer Journal
DOI: 10.1186/s12879-017-2887-6
关键词: Hepatitis CPNPLA3SteatosisFibrosisPolymorphism rs738409TM6SF2Polymorphism rs58542926Brazil
英文摘要: Prospective studies have shown that 80% of acute hepatitis C virus (HCV) cases progress to chronic infection; approximately 10-20% of patients with these conditions will develop liver cirrhosis within 2 to 3 decades, and 1-5% will develop liver cancer. Some studies have indicated that the rs738409 polymorphism of the PNPLA3 gene is associated with steatosis and the progression of advanced fibrosis. This study assessed the contribution of the PNPLA3 rs738409 polymorphism with regard to the steatosis and degree of liver fibrosis in Brazilian patients diagnosed with chronic hepatitis C.
原始语种摘要: Prospective studies have shown that 80% of acute hepatitis C virus (HCV) cases progress to chronic infection; approximately 10-20% of patients with these conditions will develop liver cirrhosis within 2 to 3 decades, and 1-5% will develop liver cancer. Some studies have indicated that the rs738409 polymorphism of the PNPLA3 gene is associated with steatosis and the progression of advanced fibrosis. This study assessed the contribution of the PNPLA3 rs738409 polymorphism with regard to the steatosis and degree of liver fibrosis in Brazilian patients diagnosed with chronic hepatitis C.
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:3.025 (2012)

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关键词翻译
关键词翻译
  • steatosis 脂肪变性
  • hepatitis 肝炎
  • fibrosis 纤维化
  • associated 相关的
  • chronic 延续很长的
  • hepatic 肝的
  • cirrhosis 硬变
  • liver 
  • Brazilian 巴西
  • polymorphism 多晶形