Acute psychoactive and toxic effects of D. metel on mice explained by 1 H NMR based metabolomics approach
作者: Yonghong FuZhihong SiPumin LiMinghui LiHe ZhaoLei JiangYuexiao XingWei HongLingyu RuanJun-Song Wang
作者单位: 1Nanjing University of Science and Technology
2Cancer Hospital, Chinese Academy of Sciences
刊名: Metabolic Brain Disease, 2017, Vol.32 (4), pp.1295-1309
来源数据库: Springer Journal
DOI: 10.1007/s11011-017-0038-9
关键词: D. metelMiceToxicityNMRMetabolomics
英文摘要: Datura metel L. ( D. metel ) is one well-known folk medical herb with wide application and also the most abused plants all over the world, mainly for spiritual or religious purpose, over-dosing of which often produces poisonous effects. In this study, mice were orally administered with the extract of D. metel once a day at doses for 10 mg/kg and 40 mg/kg for consecutive 4 days, 1H NMR based metabolomics approach aided with histopathological inspection and biochemical assays were used for the first time to study the psychoactive and toxic effects of D. metel . Histopathological inspection revealed obvious hypertrophy of hepatocytes, karyolysis and karyorrhexis in livers as well as distinct nerve cell edema, chromatolysis and lower nuclear density in brains. The increased tissue...
原始语种摘要: Datura metel L. ( D. metel ) is one well-known folk medical herb with wide application and also the most abused plants all over the world, mainly for spiritual or religious purpose, over-dosing of which often produces poisonous effects. In this study, mice were orally administered with the extract of D. metel once a day at doses for 10 mg/kg and 40 mg/kg for consecutive 4 days, 1H NMR based metabolomics approach aided with histopathological inspection and biochemical assays were used for the first time to study the psychoactive and toxic effects of D. metel . Histopathological inspection revealed obvious hypertrophy of hepatocytes, karyolysis and karyorrhexis in livers as well as distinct nerve cell edema, chromatolysis and lower nuclear density in brains. The increased tissue...
全文获取路径: Springer  (合作)
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来源刊物:
影响因子:2.333 (2012)

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关键词翻译
关键词翻译
  • approach 
  • inspection 检查
  • level 水准
  • NMR N-Modular Redundancy
  • purpose 目的
  • effects 海员自身物品
  • well 
  • discriminant 判别式
  • karyorrhexis 核破裂
  • dicarboxylic 二羧基的