Methylphenidate and Atomoxetine-Responsive Prefrontal Cortical Genetic Overlaps in “Impulsive” SHR/NCrl and Wistar Rats
| 作者： | Ike dela Peña, Irene Joy dela Peña, June Bryan de la Peña, Hee Jin Kim, Chan Young Shin, Doug Hyun Han, Bung-Nyun Kim, Jong Hoon Ryu, Jae Hoon Cheong |
| 作者单位： |
1Sahmyook University 2Loma Linda University School of Pharmacy 3Konkuk University 4Chung-Ang University Medical School 5Seoul National University College of Medicine 6College of Pharmacy, Kyung Hee University |
| 刊名： | Behavior Genetics, 2017, Vol.47 (5), pp.564-580 |
| 来源数据库： | Springer Nature Journal |
| DOI： | 10.1007/s10519-017-9861-3 |
| 关键词： | Impulsivity; Genes; SHR/NCrl; Wistar rats; Prefrontal cortex; Methylphenidate; Atomoxetine; |
| 英文摘要： | Impulsivity, the predisposition to act prematurely without foresight, is associated with a number of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Identifying genetic underpinnings of impulsive behavior may help decipher the complex etiology and neurobiological factors of disorders marked by impulsivity. To identify potential genetic factors of impulsivity, we examined common differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of adolescent SHR/NCrl and Wistar rats, which showed marked decrease in preference for the large but delayed reward, compared with WKY/NCrl rats, in the delay discounting task. Of these DEGs, we examined drug-responsive transcripts whose mRNA levels were altered following treatment (in SHR/NCrl and Wistar... |
| 原始语种摘要： | Impulsivity, the predisposition to act prematurely without foresight, is associated with a number of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Identifying genetic underpinnings of impulsive behavior may help decipher the complex etiology and neurobiological factors of disorders marked by impulsivity. To identify potential genetic factors of impulsivity, we examined common differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of adolescent SHR/NCrl and Wistar rats, which showed marked decrease in preference for the large but delayed reward, compared with WKY/NCrl rats, in the delay discounting task. Of these DEGs, we examined drug-responsive transcripts whose mRNA levels were altered following treatment (in SHR/NCrl and Wistar... |
