Methylphenidate and Atomoxetine-Responsive Prefrontal Cortical Genetic Overlaps in “Impulsive” SHR/NCrl and Wistar Rats
作者: Ike dela PeñaIrene Joy dela PeñaJune Bryan de la PeñaHee Jin KimChan Young ShinDoug Hyun HanBung-Nyun KimJong Hoon RyuJae Hoon Cheong
作者单位: 1Sahmyook University
2Loma Linda University School of Pharmacy
3Konkuk University
4Chung-Ang University Medical School
5Seoul National University College of Medicine
6College of Pharmacy, Kyung Hee University
刊名: Behavior Genetics, 2017, Vol.47 (5), pp.564-580
来源数据库: Springer Journal
DOI: 10.1007/s10519-017-9861-3
关键词: ImpulsivityGenesSHR/NCrlWistar ratsPrefrontal cortexMethylphenidateAtomoxetine
英文摘要: Impulsivity, the predisposition to act prematurely without foresight, is associated with a number of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Identifying genetic underpinnings of impulsive behavior may help decipher the complex etiology and neurobiological factors of disorders marked by impulsivity. To identify potential genetic factors of impulsivity, we examined common differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of adolescent SHR/NCrl and Wistar rats, which showed marked decrease in preference for the large but delayed reward, compared with WKY/NCrl rats, in the delay discounting task. Of these DEGs, we examined drug-responsive transcripts whose mRNA levels were altered following treatment (in SHR/NCrl and Wistar...
原始语种摘要: Impulsivity, the predisposition to act prematurely without foresight, is associated with a number of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). Identifying genetic underpinnings of impulsive behavior may help decipher the complex etiology and neurobiological factors of disorders marked by impulsivity. To identify potential genetic factors of impulsivity, we examined common differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of adolescent SHR/NCrl and Wistar rats, which showed marked decrease in preference for the large but delayed reward, compared with WKY/NCrl rats, in the delay discounting task. Of these DEGs, we examined drug-responsive transcripts whose mRNA levels were altered following treatment (in SHR/NCrl and Wistar...
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来源刊物:
影响因子:2.606 (2012)

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关键词翻译
关键词翻译
  • potential 
  • reward 报酬
  • hyperactivity 过兴奋
  • deficit 不足
  • predisposition 素质
  • genetic 遗传的
  • cortex 皮层
  • impulsive 脉冲的
  • disorder 无序
  • discounting 贴现