Genistein protects against Aβ 25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers
作者: Fuling YouQiao LiGuifang JinYaojie ZhengJingrong ChenHong Yang
作者单位: 1Guangdong Pharmaceutical University
刊名: BMC Neuroscience, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12868-016-0329-9
关键词: Alzheimer’s disease25–35ApoptosisGenisteinJNKBcl-2
原始语种摘要: Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significant protective effect against Aβ25–35 induced neurotoxicity and mitochondrial damage in rat pheochromocytoma (PC12) cells. However, the mechanisms underlying Gen’s rescue remain elusive. Therefore we endeavored to research further the molecular mechanisms underlying Gen’s inhibition of Aβ25–35 induced apoptosis of neurons.
全文获取路径: Springer Nature  (合作)
影响因子:3 (2012)

  • induced 感应的
  • against 反对
  • cells 麻风细胞
  • apoptosis 细胞死
  • signaling 发信号
  • neurotoxicity 神经中毒性
  • amyloid 淀粉状朊
  • underlying 下伏的
  • protein 蛋白质
  • inhibition 抑制